A SILENT REGULATORY GENE CFAD' ON REGION-1 OF THE CFA/I PLASMID NTP-113 OF ENTEROTOXIGENIC ESCHERICHIA-COLI

被引：10

作者：

GAASTRA, W ^{[1
]}

JORDI, BJAM ^{[1
]}

MUL, EMA ^{[1
]}

HAMERS, AM ^{[1
]}

MCCONNELL, MM ^{[1
]}

WILLSHAW, GA ^{[1
]}

SMITH, HR ^{[1
]}

VANDERZEIJST, BAM ^{[1
]}

机构：

[1] CENT PUBL HLTH LAB,DIV ENTER PATHOGENS,LONDON NW9 5HT,ENGLAND

来源：

MICROBIAL PATHOGENESIS | 1990年 / 9卷 / 04期

关键词：

ESCHERICHIA-COLI; FIMBRIAE; REGULATORY PROTEIN; NUCLEOTIDE SEQUENCE;

D O I：

10.1016/0882-4010(90)90017-K

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A DNA sequence, homologous to the cfaD gene of CFA/I region 2, was identified on CFA/I region 1. This sequence is designated cfaD′. It differs from the cfaD gene in containing two deletions and a stop codon. The cfaD′ sequence therefore can only encode a truncated CfaD-like protein. The CfaD protein may be a DNA binding protein and functions as a positive regulator of CFA/I fimbriae expression. A regulatory function for the cfaD′ is not likely since deletion of the cfaD′ sequence does not affect production of CFA/I fimbriae in E. coli K-12 strains. That the cfaD′ sequence is present on CFA/I wild-type plasmids isolated from CFA/I strains of different serotypes, obtained at various geographical locations, suggests, however, that this DNA region is not completely without a function. © 1990.

引用

页码：285 / 291

页数：7

共 23 条

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