PERICYTE PHYSIOLOGY

被引:556
作者
SHEPRO, D
MOREL, NML
机构
[1] Microvascular Research, Boston, MA 02215
关键词
BIOCHEMISTRY; ENDOTHELIUM; PERICYTES; PHYSIOLOGY; TISSUE CULTURE;
D O I
10.1096/fasebj.7.11.8370472
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Endothelial cells are the primary physical barrier between blood and tissue in microvessels. The other capillary and post-capillary venule wall cell is the pericyte. The literature on the biology of endothelium is appreciable but less is known about pericytes. Pericytes are morphologically, biochemically, and physiologically heterogeneous. Some of pericyte functional characteristics observed in vivo and in vitro are that they: regulate endothelial proliferation and differentiation; contract in manners that either exacerbate or stem endothelial cell junctional inflammatory leakage; function as a progenitor cell; synthesize and secrete a wide variety of vasoactive autoregulating agonists; synthesize and release structural constituents of the basement membrane and extracellular matrix. Pericytes are also involved in specific microvascular diseases. This review focuses principally on nonmesangial pericytes and specific activities such as the posttranslational, short-term responses that affect microvascular perfusion and permeability, and on pericyte-endothelial cell interaction.
引用
收藏
页码:1031 / 1038
页数:8
相关论文
共 63 条
[51]   INHIBITION OF ENDOTHELIAL-CELL MOVEMENT BY PERICYTES AND SMOOTH-MUSCLE CELLS - ACTIVATION OF A LATENT TRANSFORMING GROWTH FACTOR-BETA-1-LIKE MOLECULE BY PLASMIN DURING CO-CULTURE [J].
SATO, Y ;
RIFKIN, DB .
JOURNAL OF CELL BIOLOGY, 1989, 109 (01) :309-315
[52]  
SCHLINGEMANN RO, 1990, AM J PATHOL, V136, P1393
[53]   THE ISOLATION AND CULTURE OF ENDOTHELIAL-CELLS AND PERICYTES FROM THE BOVINE RETINAL MICROVASCULATURE - A COMPARATIVE-STUDY WITH LARGE VESSEL VASCULAR CELLS [J].
SCHOR, AM ;
SCHOR, SL .
MICROVASCULAR RESEARCH, 1986, 32 (01) :21-38
[54]  
SCHOR AM, 1991, IN VITRO CELL DEV B, V27, P651
[55]  
SHEPRO D, 1984, HDB PHYSL 1 2, V4, P103
[56]   EPIDERMAL GROWTH-FACTOR RECEPTOR AT ENDOTHELIAL-CELL AND PERICYTE INTERDIGITATION IN HUMAN GRANULATION-TISSUE [J].
SHIN, WK .
MICROVASCULAR RESEARCH, 1992, 44 (03) :255-262
[57]  
SHULTZ PJ, 1991, AM J KIDNEY DIS, V17, P8
[58]  
SIMONSON MS, 1992, J AM SOC NEPHROL, V2, pS116
[59]  
SIMS DE, 1991, CAN J CARDIOL, V7, P431
[60]   CONTRACTION AND RELAXATION OF CULTURED MESANGIAL CELLS ON A SILICONE-RUBBER SURFACE [J].
SINGHAL, PC ;
SCHARSCHMIDT, LA ;
GIBBONS, N ;
HAYS, RM .
KIDNEY INTERNATIONAL, 1986, 30 (06) :862-873