MOLECULAR-CLONING OF THE OLFACTORY NEURONAL TRANSCRIPTION FACTOR OLF-1 BY GENETIC SELECTION IN YEAST

被引：368

作者：

WANG, MM

REED, RR

机构：

[1] Howard Hughes Medical Institute, Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205

来源：

NATURE | 1993年 / 364卷 / 6433期

关键词：

D O I：

10.1038/364121a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A novel genetic selection in yeast has been used to isolate a complementary DNA for the transcriptional activator, Olf-1, which binds to the regulatory sequences of several olfactory-specific genes. The Olf-1 protein, expressed exclusively in the olfactory receptor neurons and their precursors, contains a new helix-loop-helix motif and functions as an apparent homodimer. Olf-1 may be the first member of a family of related proteins that may direct cellular differentiation in a variety of neuronal tissues.

引用

页码：121 / 126

页数：6

共 38 条

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