MOLECULAR-CLONING OF THE OLFACTORY NEURONAL TRANSCRIPTION FACTOR OLF-1 BY GENETIC SELECTION IN YEAST

被引：368

作者：

WANG, MM

REED, RR

机构：

[1] Howard Hughes Medical Institute, Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205

来源：

NATURE | 1993年 / 364卷 / 6433期

关键词：

D O I：

10.1038/364121a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A novel genetic selection in yeast has been used to isolate a complementary DNA for the transcriptional activator, Olf-1, which binds to the regulatory sequences of several olfactory-specific genes. The Olf-1 protein, expressed exclusively in the olfactory receptor neurons and their precursors, contains a new helix-loop-helix motif and functions as an apparent homodimer. Olf-1 may be the first member of a family of related proteins that may direct cellular differentiation in a variety of neuronal tissues.

引用

页码：121 / 126

页数：6

共 38 条

[11] ACCURATE TRANSCRIPTION INITIATION BY RNA POLYMERASE-II IN A SOLUBLE EXTRACT FROM ISOLATED MAMMALIAN NUCLEI
DIGNAM, JD
LEBOVITZ, RM
ROEDER, RG
[J]. NUCLEIC ACIDS RESEARCH, 1983, 11 (05) : 1475 - 1489
[12] EED RR, 1992, NEURON, V8, P205
[13] ENGLAND BP, 1990, J BIOL CHEM, V265, P5086
[14] GENERATION OF P50 SUBUNIT OF NF-KAPPA-B BY PROCESSING OF P105 THROUGH AN ATP-DEPENDENT PATHWAY
FAN, CM
MANIATIS, T
[J]. NATURE, 1991, 354 (6352) : 395 - 398
[15] A NOVEL GENETIC SYSTEM TO DETECT PROTEIN PROTEIN INTERACTIONS
FIELDS, S
SONG, OK
[J]. NATURE, 1989, 340 (6230) : 245 - 246
[16] ANALYSIS OF ACCURACY AND IMPLICATIONS OF SIMPLE METHODS FOR PREDICTING SECONDARY STRUCTURE OF GLOBULAR PROTEINS
GARNIER, J
OSGUTHORPE, DJ
ROBSON, B
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1978, 120 (01) : 97 - 120
[17] IMPROVED METHOD FOR HIGH-EFFICIENCY TRANSFORMATION OF INTACT YEAST-CELLS
GIETZ, D
STJEAN, A
WOODS, RA
SCHIESTL, RH
[J]. NUCLEIC ACIDS RESEARCH, 1992, 20 (06) : 1425 - 1425
[18] GORMAN CM, 1990, DNA PROTEIN ENG TECH, V2, P3
[19] GRAZIADEI PPC, 1978, OLFACTORY SYSTEM MOD, P131
[20] HUMAN AND DROSOPHILA HOMEODOMAIN PROTEINS THAT ENHANCE THE DNA-BINDING ACTIVITY OF SERUM RESPONSE FACTOR
GRUENEBERG, DA
NATESAN, S
ALEXANDRE, C
GILMAN, MZ
[J]. SCIENCE, 1992, 257 (5073) : 1089 - 1095

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