11-BETA-HYDROXYSTEROID DEHYDROGENASE-ACTIVITY IN MESENTERIC-ARTERIES OF SPONTANEOUSLY HYPERTENSIVE RATS

被引:18
作者
TAKEDA, Y [1 ]
YONEDA, T [1 ]
MIYAMORI, I [1 ]
GATHIRAM, P [1 ]
TAKEDA, R [1 ]
机构
[1] UNIV NATAL,SCH MED,DEPT PHYSIOL,DURBAN,SOUTH AFRICA
关键词
GLUCOCORTICOID; 11-BETA-HYDROXYSTEROID DEHYDROGENASE; MESENTERIC ARTERY; NOREPINEPHRINE; SHR;
D O I
10.1111/j.1440-1681.1993.tb01644.x
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
1. 11beta-Hydroxysteroid dehydrogenase (11-HSD) activity in mesenteric arteries of spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats was determined and expressed as the percentage conversion of [H-3]-corticosterone to [H-3]-11-dehydrocorticosterone. 2. 11-HSD activity was significantly decreased in mesenteric arteries of both 4 and 9 week old SHR (8.4 +/- 0.8%, 5.0 +/- 1.5%, respectively) compared with WKY rats (12.4 +/- 0.6%, 15.8 +/- 0.7%, respectively; P < 0.05). 3. Total RNA from rat vascular smooth muscle cells (VSMC) and endothelial cells (EC) were prepared with selective precipitation in 3 mol/L LiCl/6 mol/L urea. The expression of 11-HSD mRNA was confirmed in the rat VSMC but its mRNA expression was not detected in EC, using northern blot analysis. 4. The results in this study indicate that 11-HSD in the vascular wall may play a role in the pathogenesis of hypertension in SHR.
引用
收藏
页码:627 / 631
页数:5
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