DETERMINANTS OF SUSCEPTIBILITY TO CHALLENGE AND THE ANTIBODY-RESPONSE OF ADULT VOLUNTEERS GIVEN EXPERIMENTAL RESPIRATORY SYNCYTIAL VIRUS-VACCINES

被引：55

作者：

WATT, PJ

ROBINSON, BS

PRINGLE, CR

TYRRELL, DAJ

机构：

[1] HARVARD HOSP,MRC,COMMON COLD UNIT,SALISBURY,ENGLAND

[2] UNIV WARWICK,DEPT BIOL SCI,COVENTRY CV4 7AL,W MIDLANDS,ENGLAND

来源：

VACCINE | 1990年 / 8卷 / 03期

基金：

英国医学研究理事会;

关键词：

antibody responses; Respiratory syncytial virus;

D O I：

10.1016/0264-410X(90)90051-M

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The virulence and immunogenicity of a wild-type respiratory syncytial (RS) virus together with four temperature sensitive (ts) mutants derived from this isolate were tested by intranasal inoculation into adult volunteers. Resistance to challenge correlated with neutralizing antibody titres in nasal secretions and to a lesser extent in serum. All ts mutants were reduced in virulence. Mutant ts1B caused mild or asymptomatic infections yet induced antibody responses comparable with wild-type RS virus. Ts1B might be developed further to produce a live-virus vaccine. © 1990.

引用

页码：231 / 236

页数：6