PRINCIPLES OF SELECTIVE INACTIVATION OF VIRAL GENOME .8. THE INFLUENCE OF BETA-PROPIOLACTONE ON IMMUNOGENIC AND PROTECTIVE ACTIVITIES OF INFLUENZA-VIRUS

被引：28

作者：

BUDOWSKY, EI ^{[1
]}

SMIRNOV, YA ^{[1
]}

SHENDEROVICH, SF ^{[1
]}

机构：

[1] DI IVANOVSKII VIROL INST, MOSCOW, RUSSIA

来源：

VACCINE | 1993年 / 11卷 / 03期

关键词：

VIRUSES; INFLUENZA; BETA-PROPIOLACTONE; INACTIVATION; PROTECTIVITY; IMMUNOGENICITY;

D O I：

10.1016/0264-410X(93)90197-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The influence of beta-propiolactone action on the immunogenic and protective activity of the influenza virus A/WSN/33 (H1N1) has been studied. The production of antibodies against virion surface antigens in mice immunized intramuscularly by the modified virus was enhanced with the increase of inoculating dose from 6 x 10(7) to 1.5 x 10(8) viral particles per animal. The immunizing dose of 6 x 10(7) produced complete protection of immunized animals against a lethal challenge of A/WSN/33 virus. The inhibition of virus reproduction in animal lungs was increased with the increase of the virus immunizing dose up to 6 x 10(8). At a constant dose the inhibition of virus reproduction decreases with the increase of the virus modification extent.

引用

页码：343 / 348

页数：6

共 19 条

[1]

ARMSTRONG RN, 1976, HETEROCYCLES, V5, P347

[2] IN-VIVO REACTIONS OF BETA-PROPIOLACTONE [J].