VALPROIC ACID SUPPRESSES THE SYNAPTIC RESPONSE MEDIATED BY THE NMDA RECEPTORS IN RAT AMYGDALAR SLICES

被引：77

作者：

GEAN, PW ^{[1
]}

HUANG, CC ^{[1
]}

HUNG, CR ^{[1
]}

TSAI, JJ ^{[1
]}

机构：

[1] NATL CHENG KUNG UNIV,COLL MED,DEPT NEUROL,TAINAN,TAIWAN

来源：

BRAIN RESEARCH BULLETIN | 1994年 / 33卷 / 03期

关键词：

VALPROIC ACID; ANTICONVULSANT; AMYGDALA; NMDA RECEPTORS;

D O I：

10.1016/0361-9230(94)90202-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The mechanism of action of the anticonvulsant drug valproic acid (VPA) was studied in rat amygdaloid slices using intracellular recording techniques. In the presence of bicuculline (20 muM), stimulation of the endopyriform nucleus evoked an excitatory postsynaptic potential (EPSP) followed by a paroxysmal depolarizing shift (PDS). Superfusion of VPA (2 mM) reversibly suppressed the PDS. Synaptic response mediated by the N-methyl-D-aspartate (NMDA) receptors (EPSP(NMDA)) was isolated pharmacologically by application of a solution containing nonNMDA receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) and gamma-aminobutyric acid receptor antagonist bicuculline (20 muM). VPA (0.2-10 mM) reversibly reduced the amplitude of the EPSP(NMDA) in a dose-dependent manner. Higher concentration of VPA (10 mM), in addition, suppressed the normal synaptic transmission. These results suggest that VPA's anticonvulsant effect is due, at least in part, to its blocking action on the EPSP(NMDA).

引用

页码：333 / 336

页数：4

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