LACK OF ABERRANT CRYPT PROMOTION AND OF MUTAGENICITY IN EXTRACTS OF COOKED CASEIN, A COLON CANCER-PROMOTING FOOD

被引:3
作者
CORPET, DE
CASSAND, P
机构
[1] ECOLE NATL VET TOULOUSE, SECUR ALIMENTS LAB, F-31076 TOULOUSE, FRANCE
[2] UNIV BORDEAUX 1, TOXICOL ALIMENTAIRE LAB, F-33405 TALENCE, FRANCE
来源
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL | 1995年 / 24卷 / 03期
关键词
D O I
10.1080/01635589509514414
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Dietary casein cooked at 180 degrees C promotes the growth of aberrant crypt foci and colon cancer in rats initiated with azoxymethane. We speculated that promotion was due to a product that could be extracted by a solvent, such as 5-hydroxymethyl-2-furaldehyde (HMF), with tumor promoting activity or the carcinogenic heterocyclic aromatic amines (HAA). This hypothesis was tested by extracting cooked casein with solvents and water. The extracts were then 1) assayed by high-performance liquid chromatography for HMF and HAA, 2) measured for mutagenicity on a frame-shift-sensitive strain of Salmonella typhimurium, and 3) fed for 100 days to azoxymethane-initiated rats to test the promoting effect on aberrant crypt foci. Data show that 1) no HMF or HAA was detected in cooked casein, 2) no mutagenicity was detected on strain TA98, with or without metabolic activation, and 3) promotion was not associated with the extracts bur with the cooked casein residue. Therefore the promotion by cooked casein would not appear to be associated with a product that can be extracted by solvents.
引用
收藏
页码:249 / 256
页数:8
相关论文
共 37 条
[1]   COOKING METHODS, CARCINOGENS, AND DIET-CANCER STUDIES [J].
ARCHER, VE .
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 1988, 11 (02) :75-79
[2]   OBSERVATION AND QUANTIFICATION OF ABERRANT CRYPTS IN THE MURINE COLON TREATED WITH A COLON CARCINOGEN - PRELIMINARY FINDINGS [J].
BIRD, RP .
CANCER LETTERS, 1987, 37 (02) :147-151
[3]   DIET, ABERRANT CRYPT FOCI AND COLORECTAL-CANCER [J].
BRUCE, WR ;
ARCHER, MC ;
CORPET, DE ;
MEDLINE, A ;
MINKIN, S ;
STAMP, D ;
YIN, Y ;
ZHANG, XM .
MUTATION RESEARCH, 1993, 290 (01) :111-118
[4]  
CLINTON SK, 1988, CANCER RES, V48, P3035
[5]  
CORPET DE, 1990, CANCER RES, V50, P6955
[6]   COLONIC PROTEIN FERMENTATION AND PROMOTION OF COLON CARCINOGENESIS BY THERMOLYZED CASEIN [J].
CORPET, DE ;
YIN, Y ;
ZHANG, XM ;
REMESY, C ;
STAMP, D ;
MEDLINE, A ;
THOMPSON, L ;
BRUCE, WR ;
ARCHER, MC .
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 1995, 23 (03) :271-281
[7]   DIGESTION AND FERMENTATION OF PROTEINS IN RATS FED KERATIN, ALBUMIN, COOKED CASEIN AND ANTIBIOTICS [J].
CORPET, DE ;
BELLIER, R ;
PETROWITSCH, S ;
VIGOUROUX, Y .
REPRODUCTION NUTRITION DEVELOPMENT, 1994, 34 (01) :57-64
[8]   MEAT, COOKING METHODS AND COLORECTAL-CANCER - A CASE-REFERENT STUDY IN STOCKHOLM [J].
DEVERDIER, MG ;
HAGMAN, U ;
PETERS, RK ;
STEINECK, G ;
OVERVIK, E .
INTERNATIONAL JOURNAL OF CANCER, 1991, 49 (04) :520-525
[9]   OCCURRENCE, IDENTIFICATION, AND BACTERIAL MUTAGENICITY OF HETEROCYCLIC AMINES IN COOKED FOOD [J].
FELTON, JS ;
KNIZE, MG .
MUTATION RESEARCH, 1991, 259 (3-4) :205-217
[10]  
FRIEDMAN M, 1991, NUTRITIONAL TOXICOLO, V31, P447