ACTH(1-24) STIMULATES THE MIGRATION OF HUMAN MONOCYTES INVITRO

被引：17

作者：

GENEDANI, S ^{[1
]}

BERNARDI, M ^{[1
]}

BALDINI, MG ^{[1
]}

BERTOLINI, A ^{[1
]}

机构：

[1] USL 16, CTR IMMUNOHAEMATOL & TRANSFUS, I-41100 MODENA, ITALY

来源：

PEPTIDES | 1990年 / 11卷 / 06期

关键词：

ACTH; CHEMOKINESIS; MONOCYTES; NEUROPEPTIDES; IMMUNE SYSTEM; IMMUNOMODULATING PEPTIDES;

D O I：

10.1016/0196-9781(90)90164-Z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In view of the increasing evidence that a variety of stresses can influence immune responses, the direct effect of adrenocorticotropic hormone on the migration of human monocytes was studied in vitro. ACTH(1-24) significantly increased the number of migrating cells when placed in the same or the opposite compartment of the chemotaxis chamber, maximum activity being obtained at 10(-14) and 10(-8) M. The results indicate that the ACTH(1-24) directly and potently stimulates the migration of human monocytes by means of a chemokinetic effect.

引用

页码：1305 / 1307

页数：3

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