POSTERIOR CORTICAL ATROPHY - NEUROPATHOLOGIC CORRELATIONS

被引:144
作者
VICTOROFF, J
ROSS, GW
BENSON, DF
VERITY, MA
VINTERS, HV
机构
[1] UNIV CALIF LOS ANGELES,SCH MED,DEPT NEUROL,LOS ANGELES,CA
[2] UNIV CALIF LOS ANGELES,SCH MED,DEPT PATHOL,DIV NEUROPATHOL,LOS ANGELES,CA
关键词
D O I
10.1001/archneur.1994.00540150063018
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Objective: A subgroup of patients with progressive dementia has been reported with a marked predominance of symptoms attributed to the dysfunction of the posterior parieto-occipital cortex. These cases have been referred to as posterior cortical atrophy. The objective of this study was to determine whether posterior cortical atrophy is associated with distinct, uniform neuropathologic findings. Design: Three individuals with progressive dementia that began with higher visual dysfunction (posterior cortical atrophy) were followed up to definitive neuropathologic diagnosis. Results: Three separate neuropathologic entities were discovered: subcortical gliosis, Alzheimer's disease, and Creutzfeldt-Jakob disease. Conclusion: Posterior cortical atrophy is a clinically homogeneous but pathologically heterogeneous syndrome.
引用
收藏
页码:269 / 274
页数:6
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