BRAIN-DERIVED NEUROTROPHIC FACTOR EXPRESSION AFTER LONG-TERM POTENTIATION

被引：137

作者：

DRAGUNOW, M

BEILHARZ, E

MASON, B

LAWLOR, P

ABRAHAM, W

GLUCKMAN, P

机构：

[1] UNIV AUCKLAND,SCH MED,DEPT PEDIAT,AUCKLAND,NEW ZEALAND

[2] UNIV OTAGO,DEPT PSYCHOL,DUNEDIN,NEW ZEALAND

来源：

NEUROSCIENCE LETTERS | 1993年 / 160卷 / 02期

关键词：

LTP; GROWTH FACTOR; MEMORY; HIPPOCAMPUS; BDNF; RETROGRADE MESSENGER;

D O I：

10.1016/0304-3940(93)90420-P

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Long-term potentiation (LTP) of perforant-path dentate granule cell synapses, in awake rats, was followed by a time-dependent expression of brain-derived neurotrophic factor (BDNF) mRNA in dentate granule cells. This BDNF expression was blocked by the N-methyl-D-aspartate (NMDA) antagonist dizocilpine maleate (MK-801), which also blocked LTP induction, and by sodium pentobarbital, which shortens LTP persistence. These results suggest that BDNF may participate in the NMDA-receptor mediated cascade of events that result in LTP stabilization.

引用

页码：232 / 236

页数：5

共 25 条

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