YEAST REDUCTION OF SOME 4-CARBON CHLORINATED KETONES - A CONVENIENT SYNTHESIS OF (S)-(+)-BUT-3-EN-2-OL

被引：8

作者：

IBRAHIM, T

GRATTAN, TJ

WHITEHURST, JS

机构：

[1] Department of Chemistry, The University, Exeter

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1990年 / 12期

关键词：

D O I：

10.1039/p19900003317

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The action of fermenting yeast on various four-carbon chlorinated ketones has been studied. (S)-(+)-But-3-en-2-ol is conveniently prepared from (+/-)-3-chlorobutan-2-one which yields a 1:1 mixture of (2S,3S)-and (2S,3R)-3-chlorobutan-2-ols. Conversion of the mixture into the dimethylmethoxymethyl ethers followed by dehydrohalogenation and hydrolysis then gives (S)-(+)-but-3-en-2-ol.

引用

页码：3317 / 3319

页数：3