D-MEF2 - A MADS BOX TRANSCRIPTION FACTOR EXPRESSED IN DIFFERENTIATING MESODERM AND MUSCLE-CELL LINEAGES DURING DROSOPHILA EMBRYOGENESIS

被引：193

作者：

LILLY, B ^{[1
]}

GALEWSKY, S ^{[1
]}

FIRULLI, AB ^{[1
]}

SCHULZ, RA ^{[1
]}

OLSON, EN ^{[1
]}

机构：

[1] UNIV TEXAS,MD ANDERSON CANC CTR,DEPT BIOCHEM & MOLEC BIOL,HOUSTON,TX 77030

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1994年 / 91卷 / 12期

关键词：

D O I：

10.1073/pnas.91.12.5662

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The myocyte enhancer factor (MEF) 2 family of transcription factors has been implicated in the regulation of muscle transcription in vertebrates. We have cloned a protein from Drosophila, termed D-MEF2, that shares extensive amino acid homology with the MADS (MCM1, Agamous, Deficiens, and serum-response factor) domains of the vertebrate MEF2 proteins. D-mef2 gene expression is first detected during Drosophila embryogenesis within mesodermal precursor cells prior to specification of the somatic and visceral muscle lineages. Expression of D-mef2 is dependent on the mesodermal determinants twist and snail but independent of the homeobox-containing gene tinman, which is required for visceral muscle and heart development. D-mef2 expression precedes that of the MyoD homologue, nautilus, and, in contrast to nautilus, D-mef2 appears to be expressed in all somatic and visceral muscle cell precursors. Its temporal and spatial expression patterns suggest that D-mef2 may play an important role in commitment of mesoderm to myogenic lineages.

引用

页码：5662 / 5666

页数：5

共 20 条

[11] A MEF2 GENE THAT GENERATES A MUSCLE-SPECIFIC ISOFORM VIA ALTERNATIVE MESSENGER-RNA SPLICING [J].

MARTIN, JF ;

MIANO, JM ;

HUSTAD, CM ;

COPELAND, NG ;

JENKINS, NA ;

OLSON, EN .

MOLECULAR AND CELLULAR BIOLOGY, 1994, 14 (03) :1647-1656

[12] MYOCYTE ENHANCER FACTOR (MEF) 2C - A TISSUE-RESTRICTED MEMBER OF THE MEF-2 FAMILY OF TRANSCRIPTION FACTORS [J].

MARTIN, JF ;

SCHWARZ, JJ ;

OLSON, EN .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (11) :5282-5286

[13] HMEF2C GENE ENCODES SKELETAL MUSCLE-SPECIFIC AND BRAIN-SPECIFIC TRANSCRIPTION FACTORS [J].

MCDERMOTT, JC ;

CARDOSO, MC ;

YU, YT ;

ANDRES, V ;

LEIFER, D ;

KRAINC, D ;

LIPTON, SA ;

NADALGINARD, B .

MOLECULAR AND CELLULAR BIOLOGY, 1993, 13 (04) :2564-2577

[14] EXPRESSION OF A MYOD FAMILY MEMBER PREFIGURES MUSCLE PATTERN IN DROSOPHILA EMBRYOS [J].

MICHELSON, AM ;

ABMAYR, SM ;

BATE, M ;

ARIAS, AM ;

MANIATIS, T .

GENES & DEVELOPMENT, 1990, 4 (12A) :2086-2097

[15] MYOD FAMILY - A PARADIGM FOR DEVELOPMENT - COMMENT [J].

OLSON, EN .

GENES & DEVELOPMENT, 1990, 4 (09) :1454-1461

[16] THE DROSOPHILA HOMOLOG OF VERTEBRATE MYOGENIC-DETERMINATION GENES ENCODES A TRANSIENTLY EXPRESSED NUCLEAR-PROTEIN MARKING PRIMARY MYOGENIC CELLS [J].

PATERSON, BM ;

WALLDORF, U ;

ELDRIDGE, J ;

DUBENDORFER, A ;

FRASCH, M ;

GEHRING, WJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (09) :3782-3786

[17] HUMAN SRF-RELATED PROTEINS - DNA-BINDING PROPERTIES AND POTENTIAL REGULATORY TARGETS [J].

POLLOCK, R ;

TREISMAN, R .

GENES & DEVELOPMENT, 1991, 5 (12A) :2327-2341

[18] A NON-RADIOACTIVE INSITU HYBRIDIZATION METHOD FOR THE LOCALIZATION OF SPECIFIC RNAS IN DROSOPHILA EMBRYOS REVEALS TRANSLATIONAL CONTROL OF THE SEGMENTATION GENE HUNCHBACK [J].

TAUTZ, D ;

PFEIFLE, C .

CHROMOSOMA, 1989, 98 (02) :81-85

[19] THE REGULATION OF MYOGENIN GENE-EXPRESSION DURING THE EMBRYONIC-DEVELOPMENT OF THE MOUSE [J].

YEE, SP ;

RIGBY, PWJ .

GENES & DEVELOPMENT, 1993, 7 (7A) :1277-1289

[20] HUMAN MYOCYTE-SPECIFIC ENHANCER FACTOR-II COMPRISES A GROUP OF TISSUE-RESTRICTED MADS BOX TRANSCRIPTION FACTORS [J].

YU, YT ;

BREITBART, RE ;

SMOOT, LB ;

LEE, YS ;

MAHDAVI, V ;

NADALGINARD, B .

GENES & DEVELOPMENT, 1992, 6 (09) :1783-1798

← 1 2 →