MODIFICATION OF ACETYLCHOLINESTERASE AS A MECHANISM OF RESISTANCE EO INSECTICIDES

被引：284

作者：

FOURNIER, D ^{[1
]}

MUTERO, A ^{[1
]}

机构：

[1] UNIV CALIF SAN DIEGO,SCH MED,DEPT PHARMACOL,LA JOLLA,CA 92093

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY | 1994年 / 108卷 / 01期

关键词：

ACETYLCHOLINESTERASE; INSECTICIDES; MUTATED PROTEINS; RESISTANCE;

D O I：

10.1016/1367-8280(94)90084-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In insects, acetylcholinesterase is essential for life and its inhibition by organophosphorus or carbamate insecticides is lethal. Extensive use of these insecticides to control insect pests has led to resistant enzymes, less inhibited than the wild type enzyme. Some mutations responsible for resistance have been identified. The resulting mutated proteins present new catalytic properties towards substrates and inhibitors. The presence of an altered enzyme has several consequences on the genetics of resistance and maintenance of resistant alleles in natural populations.

引用

页码：19 / 31

页数：13

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