IL-4 AND IL-13, BUT NOT IL-10, ARE CHEMOTACTIC FACTORS FOR HUMAN OSTEOBLASTS

被引：56

作者：

LIND, M

DELEURAN, B

YSSEL, H

FINKERIKSEN, E

THESTRUPPEDERSEN, K

机构：

[1] AARHUS UNIV HOSP, DEPT RHEUMATOL, DK-8000 AARHUS, DENMARK

[2] AARHUS UNIV HOSP, DEPT ORTHOPED, DK-8000 AARHUS, DENMARK

[3] AARHUS UNIV HOSP, DEPT INTERNAL MED, DK-8000 AARHUS, DENMARK

[4] AARHUS UNIV HOSP, DEPT DERMATOL, DK-8000 AARHUS, DENMARK

[5] DNAX RES INST MOLEC & CELLULAR BIOL INC, PALO ALTO, CA 94304 USA

来源：

CYTOKINE | 1995年 / 7卷 / 01期

关键词：

IL-4; IL-10; IL-13; CHEMOTAXIS; OSTEOBLASTS;

D O I：

10.1006/cyto.1995.1010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this study we demonstrate that the cytokines IL-4 and IL-13, but not IL-10, can induce osteoblast chemotaxis. Recombinant IL-4 (rIL-4) and rIL-13 mediated cell migration was observed using a modified multi-well Boyden chamber system. Maximum chemotaxis was observed at concentrations of 100 ng/ml of both rIL-4 and rIL-13 with a chemotactic index of 2.0 +/- 0.1 and 2.3 +/- 0.4, respectively in this system, whereas IL-10 did not show chemotactic abilities for osteoblasts. Our results suggest that IL-4 and IL-13 could take part in the recruitment of osteoblasts and thereby be of importance in the cytokine regulation of bone resorption and healing.

引用

页码：78 / 82

页数：5

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