LOCALIZATION OF THE CELLULAR RETINOIC ACID BINDING-PROTEIN (CRABP) GENE RELATIVE TO THE ACUTE PROMYELOCYTIC LEUKEMIA-ASSOCIATED BREAKPOINT ON HUMAN CHROMOSOME-15

被引：10

作者：

VANKESSEL, AG

DELEEUW, H

DEKKER, EJ

RIJKS, L

SPURR, N

LEDBETTER, D

KOOTWIJK, E

VAESSEN, MJ

机构：

[1] NETHERLANDS INST DEV BIOL,HUBRECHT LAB,UTRECHT,NETHERLANDS

[2] ERASMUS UNIV,DEPT CELL BIOL & GENET,3000 DR ROTTERDAM,NETHERLANDS

[3] IMPERIAL CANC RES FUND,HUMAN GENET RESOURCES LAB,POTTERS BAR,ENGLAND

[4] BAYLOR UNIV,INST MOLEC GENET,HOUSTON,TX 77030

来源：

HUMAN GENETICS | 1991年 / 87卷 / 02期

关键词：

D O I：

10.1007/BF00204182

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A human genomic fragment comprising the cellular retinoic acid binding protein (CRABP) gene was isolated. By using a panel of somatic cell hybrids, this gene could be assigned to human chromosome 15. Subsequently, a possible involvement of the CRABP gene in translocation (15;17) (q22;q11) positive acute promyelocytic leukemia (APL) was investigated. Although transposition of the CRABP gene could be demonstrated, we did not observe any gross CRABP rearrangement in a series of primary APL patients, nor in the acute myeloblastic leukemia cell line HL-60. Thus, the observed lack of CRABP expression in these leukemic cells may not be caused by disruption of its gene. CRABP maps to the region 15q22-qter.

引用

页码：201 / 204

页数：4

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