CONVERSION OF A SELF PEPTIDE SEQUENCE INTO A KD-RESTRICTED NEO-ANTIGEN BY A TYR SUBSTITUTION

被引：11

作者：

HEALY, F

DROUET, C

ROMERO, P

JAULIN, C

MARYANSKI, JL

机构：

[1] LUDWIG INST CANC RES, BOVERESS 155, CH-1066 EPALINGES, SWITZERLAND

[2] INSERM, U238, F-38041 GRENOBLE, FRANCE

[3] INST PASTEUR, F-75724 PARIS 15, FRANCE

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 1991年 / 174卷 / 06期

关键词：

D O I：

10.1084/jem.174.6.1657

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We have previously found that a Tyr residue was critical for the interaction of peptides with the K(d) molecule, and therefore may be acting as an anchor residue. In the present report we show that it is possible to convert a self peptide sequence into a K(d)-restricted neo-antigen by a single Tyr substitution at position 2 of the peptide. This supports the idea that Tyr is a critical element in the binding motif of K(d)-restricted peptides and is a finding that could also prove useful for vaccine development.

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页码：1657 / 1660

页数：4

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