Adenosine A(2A) receptor stimulation enhances striatal extracellular glutamate levels in rats

被引：157

作者：

Popoli, P ^{[1
]}

Betto, P ^{[1
]}

Reggio, R ^{[1
]}

Ricciarello, G ^{[1
]}

机构：

[1] IST SUPER SANITA,DEPT DRUG CHEM,I-00161 ROME,ITALY

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1995年 / 287卷 / 02期

关键词：

adenosine A(2A) receptor; glutamate release; striatum; (rat);

D O I：

10.1016/0014-2999(95)00679-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The influence of CGS 21680, an adenosine A(2A) receptor agonist, on striatal glutamate extracellular levels was tested in a microdialysis study in rats. CGS 21680 (10 mu M), infused intrastriatally through the microdialysis probe, greatly enhanced glutamate extracellular levels. These results show that striatal adenosine A(2A) receptors are involved in the regulation of striatal glutamate extracellular levels. They also suggest that adenosine A(2A) receptor antagonists may possess neuroprotective effects in models of striatal excitotoxicity.

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收藏

页码：215 / 217

页数：3

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