CGS-15943, AN ADENOSINE-A(2) RECEPTOR ANTAGONIST, REDUCES CEREBRAL ISCHEMIC-INJURY IN THE MONGOLIAN GERBIL

被引：92

作者：

GAO, Y ^{[1
]}

PHILLIS, JW ^{[1
]}

机构：

[1] WAYNE STATE UNIV, SCH MED, DEPT PHYSIOL, DETROIT, MI 48201 USA

来源：

LIFE SCIENCES | 1994年 / 55卷 / 03期

关键词：

CEREBRAL ISCHEMIA; ADENOSINE ANTAGONIST; CGS; 15943; CEREBROPROTECTION;

D O I：

10.1016/0024-3205(94)00889-2

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The adenosine A(2) receptor antagonist CGS 15943 (0.1 mg/kg, i.p.) was tested for cerebroprotective activity in a gerbil stroke model. CGS 15943 markedly reduced stroke injury assessed by locomotor activity monitoring and by histopathological measurement of hippocampal CA1 pyramidal cell injury. It is proposed that a previously demonstrated reduction in the ischemia/reperfusion-evoked release of excitotoxic amino acids following CGS 15943 administration could account for its cerebroprotective actions.

引用

页码：PL61 / PL65

页数：5

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