STRIATAL PROTECTION INDUCED BY LESIONING THE SUBSTANTIA-NIGRA OF RATS SUBJECTED TO FOCAL ISCHEMIA

被引：91

作者：

BUISSON, A

CALLEBERT, J

MATHIEU, E

PLOTKINE, M

BOULU, RG

机构：

[1] Laboratoire de Pharmacologie, Faculté Des Sciences Pharmaceutiques Et Biologiques, Université René Descartes, Paris

来源：

JOURNAL OF NEUROCHEMISTRY | 1992年 / 59卷 / 03期

关键词：

SUBSTANTIA-NIGRA LESION; NIGROSTRIATAL PATHWAY; STRIATUM VULNERABILITY; CEREBRAL FOCAL ISCHEMIA; GLUTAMATE; DOPAMINE INTERACTIONS; MICRODIALYSIS;

D O I：

10.1111/j.1471-4159.1992.tb08358.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Unilateral 6-hydroxydopamine lesion of the substantia nigra reduced the volume of striatal necrosis and suppressed the increase in extracellular glutamate concentration in the striatum induced by middle cerebral artery occlusion in rats. These results indicate that the dopaminergic nigrostriatal pathway is highly involved in the vulnerability of the striatum to ischemia and suggest that glutamate-dopamine interactions may play a key role in the striatal ischemic insult.

引用

页码：1153 / 1157

页数：5

共 38 条

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