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THE DYNAMIC ROLE OF PALMITOYLATION IN SIGNAL-TRANSDUCTION

被引：288
作者：
MILLIGAN, G
PARENTI, M
MAGEE, AI
机构：
[1] UNIV MILAN,DEPT PHARMACOL,I-20129 MILAN,ITALY
[2] NATL INST MED RES,EUKARYOT MOLEC GENET LAB,LONDON NW7 1AA,ENGLAND
来源：
TRENDS IN BIOCHEMICAL SCIENCES | 1995年 / 20卷 / 05期
基金：
英国医学研究理事会;
关键词：
D O I：
10.1016/S0968-0004(00)89004-0
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Guanine nucleotide binding protein (G protein)-linked receptors, the alpha-subunits of heterotrimeric G proteins and members of the Src family of non-receptor tyrosine kinases are among many polypeptides that are post-translationally modified by the addition of palmitate, a long-chain fatty acid. Attachment of palmitate to these proteins is dynamic and may be regulated by their activation. The presence of palmitate appears to play a key role in the membrane localization of either the entire polypeptide or parts of it, and may regulate the interactions of these polypeptides with other proteins.
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页码：181 / 186
页数：6
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