THE DYNAMIC ROLE OF PALMITOYLATION IN SIGNAL-TRANSDUCTION

被引：288

作者：

MILLIGAN, G

PARENTI, M

MAGEE, AI

机构：

[1] UNIV MILAN,DEPT PHARMACOL,I-20129 MILAN,ITALY

[2] NATL INST MED RES,EUKARYOT MOLEC GENET LAB,LONDON NW7 1AA,ENGLAND

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1995年 / 20卷 / 05期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/S0968-0004(00)89004-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Guanine nucleotide binding protein (G protein)-linked receptors, the alpha-subunits of heterotrimeric G proteins and members of the Src family of non-receptor tyrosine kinases are among many polypeptides that are post-translationally modified by the addition of palmitate, a long-chain fatty acid. Attachment of palmitate to these proteins is dynamic and may be regulated by their activation. The presence of palmitate appears to play a key role in the membrane localization of either the entire polypeptide or parts of it, and may regulate the interactions of these polypeptides with other proteins.

引用

页码：181 / 186

页数：6

共 56 条

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