ENANTIOMERS RESOLUTION IN CAPILLARY ZONE ELECTROPHORESIS BY USING CYCLODEXTRINS

被引：54

作者：

SCHUTZNER, W ^{[1
]}

FANALI, S ^{[1
]}

机构：

[1] CNR,IST CROMATOG,POB 10,I-00016 MONTEROTONDO,ITALY

来源：

ELECTROPHORESIS | 1992年 / 13卷 / 9-10期

关键词：

D O I：

10.1002/elps.11501301146

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Cyclodextrins added to the background electrolyte are shown to be useful for the resolution of racemic compounds in their enantiomers. Several parameters have to be controlled in order to achieve resolution, e.g., cyclodextrin type, concentration, analyte shape, as well as column temperature. The resolution of nor-epinephrine, epinephrine and isoproterenol in their enantiomers decreased by increasing the column temperature. Octopamine and ketamine have been resolved by supporting the background electrolyte with 2, 6-di-O-methyl-beta-cyclodextrin. In spite of the stronger inclusion-complex of ketamine than octopamine with the modified cyclodextrin its resolution was not satisfactory.

引用

页码：687 / 690

页数：4

共 23 条

[1] PHARMACOKINETICS OF THE ENANTIOMERS OF TERBUTALINE AFTER REPEATED ORAL DOSING WITH RACEMIC TERBUTALINE [J].