OCCURRENCE OF GD3 GANGLIOSIDE IN REACTIVE ASTROCYTES - AN IMMUNOCYTOCHEMICAL STUDY IN THE RAT-BRAIN

被引：24

作者：

KAWAI, K ^{[1
]}

KURODA, S ^{[1
]}

WATARAI, S ^{[1
]}

TAKAHASHI, H ^{[1
]}

IKUTA, F ^{[1
]}

机构：

[1] NIIGATA UNIV, BRAIN RES INST, DEPT PATHOL, NIIGATA 951, JAPAN

来源：

NEUROSCIENCE LETTERS | 1994年 / 174卷 / 02期

关键词：

REACTIVE ASTROCYTE; ULTRASTRUCTURE; RAT; GANGLIOSIDE GD3; MONOCLONAL ANTIBODY; IMMUNOCYTOCHEMISTRY;

D O I：

10.1016/0304-3940(94)90027-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Immunocytochemical study of ganglioside GD3 (II3 alpha(NeuAc alpha 2-8NeuAc)-LacCer) was performed in the cold lesions produced in the cerebral cortex of the rat brain, using mouse IgM anti-GD3 monoclonal antibody (DSG-1). Seven and 15 days after cold lesioning, GD3-like immunoreactivity was observed in reactive astrocytes. Thirty and 50 days after cold lesioning, GD3-like immunoreactivity was observed in the cells that formed glial scars. Normal astrocytes were not immunoreactive. Therefore, it is possible that GD3 may play an important role in the astrocytic functions required for the process of repair of edematous lesions in the central nervous system.

引用

页码：225 / 227

页数：3

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