EFFECT OF PLATELET-DERIVED GROWTH FACTOR-BB ON INDOMETHACIN-INDUCED GASTRIC-LESIONS IN RATS

被引：20

作者：

GUGLIETTA, A ^{[1
]}

HERVADA, T ^{[1
]}

NARDI, RV ^{[1
]}

LESCH, CA ^{[1
]}

机构：

[1] GLAXO RES LABS,RES TRIANGLE PK,NC

来源：

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY | 1992年 / 27卷 / 08期

关键词：

GASTRIC ACID; GASTRIC DAMAGE; INDOMETHACIN; PLATELET-DERIVED GROWTH FACTOR;

D O I：

10.3109/00365529209000138

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The effect of platelet-derived growth factor-BB (PDGF-BB) was evaluated in rats with indomethacin-induced gastric lesions. Animals were treated with either saline solution or several doses of PDGF-BB given orally. Rats treated with 0.1 nmol/kg PDGF-BB showed a statistically significant reduction of gastric damage. Higher doses did not produce any further reduction of gastric damage, and a return toward control values was observed. The effect on lesions was independent of inhibition of gastric acid secretion, since a dose of 0.1 nmol/kg of this growth factor failed to modify gastric acid secretion stimulated by pylorus ligation.

引用

页码：673 / 676

页数：4

共 15 条

[1] EPIDERMAL GROWTH-FACTOR INHIBITS GROWTH OF A431 HUMAN EPIDERMOID CARCINOMA IN SERUM-FREE CELL-CULTURE [J].