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INVIVO BRAIN DIALYSIS OF NEUROTRANSMITTERS

被引：155
作者：
DICHIARA, G
机构：
[1] University of Cagliari, 09100 Cagliari
来源：
TRENDS IN PHARMACOLOGICAL SCIENCES | 1990年 / 11卷 / 03期
关键词：
(3α-tropanyl)-1H-indole-3-carboxylic acid ester; 1αH3α-(5αH-tropan-3-yl)-3,5-dichiorobenzoate; ICS205930; MDL72222; R-(+)-8-chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepine-7-ol; SCH23390;
D O I：
10.1016/0165-6147(90)90197-G
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Centrally acting drugs interfere with the function of central neurotransmitter systems. This often requires intact neuronal connections and is therefore best studied in vivo. Here, Gaetano Di Chiara describes the technique of brain dialysis, which permits direct in-vivo sampling of neurotransmitters and their metabolites in the brain extracellular fluid. This technique is now providing insight correlating the interaction of drugs with neurotransmission in specific brain areas with their effects on behaviour. © 1990.
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页码：116 / 121
页数：6
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