EFFECT OF TUMOR BURDEN AND ROUTE OF ADMINISTRATION ON THE IMMUNOTHERAPEUTIC PROPERTIES OF POLYINOSINIC POLYCYTIDYLIC ACID STABILIZED WITH POLY-L-LYSINE IN CARBOXYMETHYL CELLULOSE [POLY(I,C)-LC]

被引:11
作者
BLACK, PL
HARTMANN, D
PENNINGTON, R
PHILLIPS, H
SCHNEIDER, M
TRIBBLE, HR
TALMADGE, JE
机构
[1] NIPPON LAROCHE,KANAGAWA 247,JAPAN
[2] NIH,FREDERICK CANC RES,PRECLIN SCREENING LAB,FREDERICK,MD 21702
[3] SMITHKLINE BEECHAM PHARMACEUT,KING OF PRUSSIA,PA 19406
[4] UNIV NEBRASKA,MED CTR,OMAHA,NE 68198
来源
INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY | 1992年 / 14卷 / 08期
关键词
D O I
10.1016/0192-0561(92)90005-6
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
We examined the immunomodulatory and therapeutic activities of poly(I,C) - LC. Mice received a subcutaneous (s.c.) injection of sufficient numbers of MBL-2 lymphoma cells to produce in 1 week either a high or low tumor burden. A week after tumor cell injection, poly(I,C) - LC treatment was initiated; the agent was administered intraperitoneally (i.p.) at 5 mg/kg twice a week or at 2.5 or 0.5 mg/kg every day or as an intravenous (i.v.) injection at 0.5, 0.05, or 0.005 mg/kg three times a week. Poly(I,C) - LC treatment significantly increased antitumor effector cell functions in a variety of organs (including spleen, lungs, and peritoneum), as shown by increased killing of MBL-2 cells in vitro and increased tumor cell killing by natural killer cells and macrophages. Furthermore, prolongation of survival correlated with peritoneal macrophage tumoricidal activity when poly(I,C) - LC was given i.p. and with pulmonary effector cell function (including natural killer, cytolytic T-lymphocyte and macrophage tumoricidal activity) when the agent was administered i.v.
引用
收藏
页码:1341 / 1353
页数:13
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