SLOW AND MEDIUM AFTERHYPERPOLARIZATIONS IN MATURING RAT HIPPOCAMPAL CA1 NEURONS

被引：7

作者：

COSTA, PF

SANTOS, AI

RIBEIRO, MA

机构：

[1] Departamento de Fisiologia, Universidade Nova de Lisboa, Lisbon, Campo Santana

来源：

NEUROREPORT | 1992年 / 3卷 / 07期

关键词：

DEVELOPMENT; MATURATION; HIPPOCAMPUS; CA1; AFTERHYPERPOLARIZATION; NORADRENALINE RECEPTORS;

D O I：

10.1097/00001756-199207000-00002

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

THE postnatal evolution of the signals underlying the afterhyperpolarization (slow-AHP and medium-AHP) was studied in rat CA1 hippocampal neurones (P10-16, P17-23 and P > 26) using in vitro slices. Noradrenaline (NA) and signal subtraction were used to decompose the AHP (m-AHP and s-AHP). The amplitude of the s-AHP was found significant between P10-16 and P17-23 cells; the m-AHP showed no significant change. The time to peak of the s-AHP of the P > 26 cells was found to be significantly different from the remaining groups; the m-AHP showed no significant change. The changes in waveform and amplitude of the AHP at this stage were found to be mainly due to the modifications of the slow-AHP.

引用

页码：555 / 558

页数：4

共 12 条

[1] AFTERPOTENTIAL CHARACTERISTICS AND FIRING PATTERNS IN MATURING RAT HIPPOCAMPAL CA1 NEURONS IN INVITRO SLICES [J].

COSTA, PF ;

RIBEIRO, MA ;

SANTOS, AI .

DEVELOPMENTAL BRAIN RESEARCH, 1991, 62 (02) :263-272

[2]

COSTA PF, 1991, 14TH ANN ENA M CAMBR

[3] CALCIUM-ACTIVATED HYPERPOLARIZATION FOLLOWS REPETITIVE FIRING IN HIPPOCAMPAL-NEURONS [J].

HOTSON, JR ;

PRINCE, DA .

JOURNAL OF NEUROPHYSIOLOGY, 1980, 43 (02) :409-419

[4] CALCIUM-DEPENDENT CURRENT GENERATING THE AFTERHYPERPOLARIZATION OF HIPPOCAMPAL-NEURONS [J].

LANCASTER, B ;

ADAMS, PR .

JOURNAL OF NEUROPHYSIOLOGY, 1986, 55 (06) :1268-1282

[5]

Langmoen I, 1981, ELECTROPHYSIOLOGY IS, P51

[6] NORADRENALINE BLOCKS ACCOMMODATION OF PYRAMIDAL CELL DISCHARGE IN THE HIPPOCAMPUS [J].

MADISON, DV ;

NICOLL, RA .

NATURE, 1982, 299 (5884) :636-638

[7] CONTROL OF THE REPETITIVE DISCHARGE OF RAT CA1 PYRAMIDAL NEURONS INVITRO [J].

MADISON, DV ;

NICOLL, RA .

JOURNAL OF PHYSIOLOGY-LONDON, 1984, 354 (SEP) :319-331

[8] ACTIONS OF NORADRENALINE RECORDED INTRACELLULARLY IN RAT HIPPOCAMPAL CA1 PYRAMIDAL NEURONS, INVITRO [J].

MADISON, DV ;

NICOLL, RA .

JOURNAL OF PHYSIOLOGY-LONDON, 1986, 372 :221-244

[9] CYCLIC ADENOSINE-3',5'-MONOPHOSPHATE MEDIATES BETA-RECEPTOR ACTIONS OF NORADRENALINE IN RAT HIPPOCAMPAL PYRAMIDAL CELLS [J].

MADISON, DV ;

NICOLL, RA .

JOURNAL OF PHYSIOLOGY-LONDON, 1986, 372 :245-259

[10] CHARACTERISTICS OF CA1 NEURONS RECORDED INTRACELLULARLY IN HIPPOCAMPAL INVITRO SLICE PREPARATION [J].

SCHWARTZKROIN, PA .

BRAIN RESEARCH, 1975, 85 (03) :423-436

← 1 2 →