SLOW AND MEDIUM AFTERHYPERPOLARIZATIONS IN MATURING RAT HIPPOCAMPAL CA1 NEURONS

被引：7

作者：

COSTA, PF

SANTOS, AI

RIBEIRO, MA

机构：

[1] Departamento de Fisiologia, Universidade Nova de Lisboa, Lisbon, Campo Santana

来源：

NEUROREPORT | 1992年 / 3卷 / 07期

关键词：

DEVELOPMENT; MATURATION; HIPPOCAMPUS; CA1; AFTERHYPERPOLARIZATION; NORADRENALINE RECEPTORS;

D O I：

10.1097/00001756-199207000-00002

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

THE postnatal evolution of the signals underlying the afterhyperpolarization (slow-AHP and medium-AHP) was studied in rat CA1 hippocampal neurones (P10-16, P17-23 and P > 26) using in vitro slices. Noradrenaline (NA) and signal subtraction were used to decompose the AHP (m-AHP and s-AHP). The amplitude of the s-AHP was found significant between P10-16 and P17-23 cells; the m-AHP showed no significant change. The time to peak of the s-AHP of the P > 26 cells was found to be significantly different from the remaining groups; the m-AHP showed no significant change. The changes in waveform and amplitude of the AHP at this stage were found to be mainly due to the modifications of the slow-AHP.

引用

页码：555 / 558

页数：4