IDENTIFICATION OF THE METABOTROPIC GLUTAMATE RECEPTOR-1 PROTEIN IN THE RAT TRIGEMINAL GANGLION

被引：11

作者：

ARAKI, T

KENIMER, JG

NISHIMUNE, A

SUGIYAMA, H

YOSHIMURA, R

KIYAMA, H

机构：

[1] OSAKA UNIV,SCH MED,DEPT NEUROANAT,BIOMED RES CTR,SUITA,OSAKA 565,JAPAN

[2] US FDA,CELLULAR PHYSIOL LAB,BETHESDA,MD 20892

[3] KYUSHU UNIV,FAC SCI,DEPT BIOL,FUKUOKA 812,JAPAN

来源：

BRAIN RESEARCH | 1993年 / 627卷 / 02期

关键词：

MGLUR1; SOMATIC SENSATION; MONOCLONAL ANTIBODY; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; TRIGEMINAL GANGLION;

D O I：

10.1016/0006-8993(93)90339-O

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Anti-metabotropic glutamate receptor-1 monoclonal antibody was raised and applied for immunohistochemistry in the rat trigeminal ganglion. The antibody detected 145-kDa single band of protein in the immunoblot analysis. In immunohistochemistry, neurons in the trigeminal ganglion showed immunostaining with various intensity, almost irrespective of their cell size. The results indicate that metabotropic glutamate receptors play an important role in somatic sensation together with ionotropic ones.

引用

页码：341 / 344

页数：4

共 34 条

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ABE T, 1992, J BIOL CHEM, V267, P13361

[2] SIGNAL TRANSDUCTION AND PHARMACOLOGICAL CHARACTERISTICS OF A METABOTROPIC GLUTAMATE RECEPTOR, MGLUR1, IN TRANSFECTED CHO CELLS [J].