学术探索
学术期刊
新闻热点
数据分析
智能评审

IDENTIFICATION OF THE METABOTROPIC GLUTAMATE RECEPTOR-1 PROTEIN IN THE RAT TRIGEMINAL GANGLION

被引：11
作者：
ARAKI, T
KENIMER, JG
NISHIMUNE, A
SUGIYAMA, H
YOSHIMURA, R
KIYAMA, H
机构：
[1] OSAKA UNIV,SCH MED,DEPT NEUROANAT,BIOMED RES CTR,SUITA,OSAKA 565,JAPAN
[2] US FDA,CELLULAR PHYSIOL LAB,BETHESDA,MD 20892
[3] KYUSHU UNIV,FAC SCI,DEPT BIOL,FUKUOKA 812,JAPAN
来源：
BRAIN RESEARCH | 1993年 / 627卷 / 02期
关键词：
MGLUR1; SOMATIC SENSATION; MONOCLONAL ANTIBODY; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; TRIGEMINAL GANGLION;
D O I：
10.1016/0006-8993(93)90339-O
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Anti-metabotropic glutamate receptor-1 monoclonal antibody was raised and applied for immunohistochemistry in the rat trigeminal ganglion. The antibody detected 145-kDa single band of protein in the immunoblot analysis. In immunohistochemistry, neurons in the trigeminal ganglion showed immunostaining with various intensity, almost irrespective of their cell size. The results indicate that metabotropic glutamate receptors play an important role in somatic sensation together with ionotropic ones.
引用
收藏
页码：341 / 344
页数：4
相关论文
共 34 条
[11]   CLONING BY FUNCTIONAL EXPRESSION OF A MEMBER OF THE GLUTAMATE RECEPTOR FAMILY [J].
HOLLMANN, M ;
OSHEAGREENFIELD, A ;
ROGERS, SW ;
HEINEMANN, S .
NATURE, 1989, 342 (6250) :643-648
[12]   RESPONSES OF RENSHAW CELLS AND SPINAL INTERNEURONES OF RAT TO L-GLUTAMATE AND L-ASPARTATE [J].
HUTCHINSON, GB ;
MCLENNAN, H ;
WHEAL, HV .
BRAIN RESEARCH, 1978, 141 (01) :129-136
[13]  
JOHNSON J L, 1970, Brain Research, V24, P285, DOI 10.1016/0006-8993(70)90107-1
[14]   DISTRIBUTION OF GLUTAMATE AND TOTAL FREE AMINO ACIDS IN 13 SPECIFIC REGIONS OF CAT CENTRAL NERVOUS SYSTEM [J].
JOHNSON, JL ;
APRISON, MH .
BRAIN RESEARCH, 1971, 26 (01) :141-&
[15]  
JOHNSON JL, 1986, LIFE SCI, V20
[16]   GLUTAMATE-IMMUNOREACTIVITY IN THE TRIGEMINAL AND DORSAL-ROOT GANGLIA, AND INTRASPINAL NEURONS AND FIBERS IN THE DORSAL HORN OF THE RAT [J].
KAIKAI, MA ;
HOWE, R .
HISTOCHEMICAL JOURNAL, 1991, 23 (04) :171-179
[17]   A FAMILY OF AMPA-SELECTIVE GLUTAMATE RECEPTORS [J].
KEINANEN, K ;
WISDEN, W ;
SOMMER, B ;
WERNER, P ;
HERB, A ;
VERDOORN, TA ;
SAKMANN, B ;
SEEBURG, PH .
SCIENCE, 1990, 249 (4968) :556-560
[18]   SUBSTANCE-P RECEPTOR (NK-1) IN THE CENTRAL-NERVOUS-SYSTEM - POSSIBLE FUNCTIONS FROM A MORPHOLOGICAL ASPECT [J].
KIYAMA, H ;
MAENO, H ;
TOHYAMA, M .
REGULATORY PEPTIDES, 1993, 46 (1-2) :114-123
[19]  
LAEMMLI UK, 1970, NATURE LONDON, V227
[20]   CELLULAR-LOCALIZATION OF A METABOTROPIC GLUTAMATE RECEPTOR IN RAT-BRAIN [J].
MARTIN, LJ ;
BLACKSTONE, CD ;
HUGANIR, RL ;
PRICE, DL .
NEURON, 1992, 9 (02) :259-270
1234