KETONE-BODIES INHIBIT LEUCINE DEGRADATION IN CHICK SKELETAL-MUSCLE

被引：34

作者：

WU, G

THOMPSON, JR

机构：

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY | 1987年 / 19卷 / 10期

关键词：

D O I：

10.1016/0020-711X(87)90175-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

1. DL-.beta.-hydroxybutyrate (4 mM) increased the net rate of leucine transamination and the net rate of 2-oxoisocaproate (KIC) production in extensor digitorum communis muscles from fed chicks. 2. DL-.beta.-hydroxybutyrate at 1 and 4 mM inhibited leucine oxidative decarboxylation in muscles from fed chicks. 3. Acetoacetate at 1 and 4 mM inhibited leucine oxidative decarboxylation and total leucine oxidation, but increased net KIC production in muscles from fed chicks. 4. Both DL-.beta.-hydroxybutyrate and acetoacetate at 1 and 4 mM inhibited the net rate of leucine transamination and the rates of leucine oxidative decarboxylation and total leucine oxidation in muscles from 24-hr fasted chicks.

引用

页码：937 / 943

页数：7

共 25 条

[1]

CATABOLISM OF BRANCHED-CHAIN AMINO-ACIDS BY DIAPHRAGM MUSCLES OF FASTED AND DIABETIC RATS [J].