IGG SUBTYPE IS CORRELATED WITH EFFICIENCY OF PASSIVE PROTECTION AND EFFECTOR FUNCTION OF ANTI-HERPES SIMPLEX VIRUS GLYCOPROTEIN-D MONOCLONAL-ANTIBODIES

被引：50

作者：

ISHIZAKA, ST ^{[1
]}

PIACENTE, P ^{[1
]}

SILVA, J ^{[1
]}

MISHKIN, EM ^{[1
]}

机构：

[1] LEDERLE PRAXIS BIOL,DEPT VIRAL VACCINE RES & DEV,PEARL RIVER,NY 10965

来源：

JOURNAL OF INFECTIOUS DISEASES | 1995年 / 172卷 / 04期

关键词：

D O I：

10.1093/infdis/172.4.1108

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

IgG subclasses differ in their effector functions in a variety of in vitro assays. To assess the effect of antibody subclass differences on in vivo protective efficacy against herpes simplex virus (HSV), a series of subclass switch mutants was made from an anti-HSV glycoprotein D monoclonal antibody. Purified antibody was examined for the ability to protect against HSV-2 challenge in mice. IgG2a was found to be more effective than IgG1. This correlated both with activity in antibody-dependent cell-mediated cytotoxicity and with efficiency of complement-mediated neutralization. These data suggest that optimization of passive immunization against HSV requires consideration of antibody subclass.

引用

页码：1108 / 1111

页数：4

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