Circulating tumor cells and epithelial, mesenchymal and stemness markers: characterization of cell subpopulations

被引：124

作者：

Barriere, Guislaine ^{[1
]}

Fici, Pietro ^{[1
]}

Gallerani, Giulia ^{[1
]}

Fabbri, Francesco ^{[1
]}

Zoli, Wainer ^{[1
]}

Rigaud, Michel ^{[1
]}

机构：

[1] IRCCS, Ist Sci Romagnolo Studio & Cura Tumori IRST, Via Piero Maroncelli 40, I-47014 Meldola, FC, Italy

来源：

ANNALS OF TRANSLATIONAL MEDICINE | 2014年 / 2卷 / 11期

关键词：

Circulating tumor cells (CTCs); epithelial mesenchymal transition (EMT); stemness;

D O I：

10.3978/j.issn.2305-5839.2014.10.04

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Until now detection and numeration of circulating tumor cells (CTCs) were essentially used as a prognostic factor in cancer progression. To extend the role of these kinds of analysis, it seems necessary to improve analytical methods related to isolation and characterization of CTCs. Discrepancies between published results corroborates this requirement. In this review we suggest a combination of markers able to reach the goal. Moreover to improve the clinical utility of CTC analysis, particularly in the therapeutic follow up of the disease, epithelial mesenchymal transition (EMT) level of a global CTC population should be studied.

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页数：8

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