EXPRESSION OF THE CD4 GENE REQUIRES A MYB TRANSCRIPTION FACTOR

被引:138
作者
SIU, G
WURSTER, AL
LIPSICK, JS
HEDRICK, SM
机构
[1] UNIV CALIF SAN DIEGO, CTR CANC, LA JOLLA, CA 92093 USA
[2] SUNY STONY BROOK, SCH MED, DEPT MICROBIOL, STONY BROOK, NY 11794 USA
关键词
D O I
10.1128/MCB.12.4.1592
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
We have analyzed the control of developmental expression of the CD4 gene, which encodes an important recognition molecule and differentiation antigen on T cells. We have determined that the CD4 promoter alone functions at high levels in the CD4+ CD8- mature T cell but not at the early CD4+ CD8+ stage of T-cell development. In addition, the CD4 promoter functions only in T lymphocytes; thus, the stage and tissue specificity of the CD4 gene is mediated in part by its promoter. We have determined that a Myb transcription factor binds to the CD4 promoter and is critical for full promoter function. Thus, Myb plays an important role in the expression of T-cell-specific developmentally regulated genes.
引用
收藏
页码:1592 / 1604
页数:13
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