LARGE-CELL ANAPLASTIC LYMPHOMA-SPECIFIC TRANSLOCATION (T[2-5] [P23-Q35]) IN HODGKINS-DISEASE - INDICATION OF A COMMON PATHOGENESIS

被引:99
作者
ORSCHESCHEK, K
MERZ, H
HELL, J
BINDER, T
BARTELS, H
FELLER, AC
机构
[1] UNIV LUBECK,DEPT PATHOL,D-23538 LUBECK,GERMANY
[2] UNIV ULM,DEPT INTERNAL MED 3,W-7900 ULM,GERMANY
[3] STADT KRANKENHAUS SUD,DEPT HEMATOL ONCOL,LUBECK,GERMANY
来源
LANCET | 1995年 / 345卷 / 8942期
关键词
D O I
10.1016/S0140-6736(95)90061-6
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Chromosomal aberrations are characteristic and specific events; the detection of chromosomal abnormalities often provides information on diagnosis and prognosis of disease. Some patients with large-cell anaplastic lymphoma (Ki 1 lymphoma) have the translocation t(2;5) (p23; q35), involving a possible growth-regulating tyrosine kinase. We found this translocation in 11 patients with Hodgkin's disease of nodular sclerosis and mixed-cellularity types. This finding has implications for the understanding of the relation between large-cell anaplastic lymphoma and Hodgkin's disease, diseases with morphological and immunophenotypical similarities. Study of this translocation may help understanding of the origins of cancer and cancer growth. It also allows a more precise definition of Hodgkin's disease and may be used as an indicator for clonality-which has long been sought.
引用
收藏
页码:87 / 90
页数:4
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