COMBINED HISTOCHEMICAL AND BIOCHEMICAL DEMONSTRATION OF NIGRAL VULNERABILITY TO LIPID-PEROXIDATION INDUCED BY DOPA AND IRON

被引：30

作者：

TANAKA, M

SOTOMATSU, A

KANAI, H

HIRAI, S

机构：

来源：

NEUROSCIENCE LETTERS | 1992年 / 140卷 / 01期

关键词：

SUBSTANTIA-NIGRA; CAUDATE-PUTAMEN; DOPA; IRON; LIPID PEROXIDATION; PARKINSONS DISEASE; ALPHA-TOCOPHEROL;

D O I：

10.1016/0304-3940(92)90677-Y

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Using a newly developed lipid peroxidation-inducing system composed of DOPA and iron, we examined the vulnerability of substantia nigra to peroxidation in comparison with that of caudate-putamen obtained from normal or vitamin E-deficient animals. Histochemical detection of lipid peroxidation revealed that substantia nigra was far more susceptible than caudate putamen to DOPA and iron treatment, which was biochemically supported by measurements of thiobarbituric acid-reactive substances. Vitamin E deficiency accelerated such susceptibility of substantia nigra but had no influence on the histochemical findings observed in caudate-putamen.

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页码：42 / 46

页数：5

相关论文

共 15 条

[1] BASAL LIPID-PEROXIDATION IN SUBSTANTIA NIGRA IS INCREASED IN PARKINSONS-DISEASE [J].

DEXTER, DT ;

CARTER, CJ ;

WELLS, FR ;

JAVOYAGID, F ;

AGID, Y ;

LEES, A ;

JENNER, P ;

MARSDEN, CD .

JOURNAL OF NEUROCHEMISTRY, 1989, 52 (02) :381-389

[2]

Jellinger K., 1986, RECENT DEV PARKINSON, P33

[3] PERTURBATIONS IN CEREBRAL OXYGEN RADICAL FORMATION AND MEMBRANE ORDER FOLLOWING VITAMIN-E DEFICIENCY [J].

LEBEL, CP ;

ODUNZE, IN ;

ADAMS, JD ;

BONDY, SC .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1989, 163 (02) :860-866

[4]

LOWRY OH, 1951, J BIOL CHEM, V193, P265

[5] EFFECTS OF A PROLONGED VITAMIN-E-DEFICIENCY IN RAT [J].

MACHLIN, LJ ;

FILIPSKI, R ;

NELSON, J ;

HORN, LR ;

BRIN, M .

JOURNAL OF NUTRITION, 1977, 107 (07) :1200-1208

[6] EFFECT OF VITAMIN-E ADMINISTRATION ON ALPHA-TOCOPHEROL CONCENTRATIONS IN THE RETINA, CHOROID, AND VITREOUS BODY OF HUMAN NEONATES [J].

NISHIDA, A ;

TOGARI, H .

JOURNAL OF PEDIATRICS, 1986, 108 (01) :150-153

[7] ASSAY FOR LIPID PEROXIDES IN ANIMAL-TISSUES BY THIOBARBITURIC ACID REACTION [J].

OHKAWA, H ;

OHISHI, N ;

YAGI, K .

ANALYTICAL BIOCHEMISTRY, 1979, 95 (02) :351-358

[8]

POMPELLA A, 1987, AM J PATHOL, V129, P295

[9] TRANSITION-METALS, FERRITIN, GLUTATHIONE, AND ASCORBIC-ACID IN PARKINSONIAN BRAINS [J].

RIEDERER, P ;

SOFIC, E ;

RAUSCH, WD ;

SCHMIDT, B ;

REYNOLDS, GP ;

JELLINGER, K ;

YOUDIM, MBH .

JOURNAL OF NEUROCHEMISTRY, 1989, 52 (02) :515-520

[10] PHOSPHOLIPID PEROXIDATION INDUCED BY THE CATECHOL-FE-3+(CU-2+) COMPLEX - A POSSIBLE MECHANISM OF NIGROSTRIATAL CELL-DAMAGE [J].

SOTOMATSU, A ;

NAKANO, M ;

HIRAI, S .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1990, 283 (02) :334-341