SENSITIVITY OF TRANSIENT OUTWARD RECTIFICATION TO ION CHANNEL BLOCKING-AGENTS IN GUINEA-PIG SUBSTANTIA-NIGRA PARS COMPACTA NEURONS INVITRO

被引：10

作者：

HARRIS, NC

机构：

[1] University Department of Pharmacology, Oxford

来源：

BRAIN RESEARCH | 1992年 / 596卷 / 1-2期

关键词：

APAMIN; BARIUM; CESIUM; CADMIUM; ION CHANNEL BLOCKER; INTRACELLULAR RECORDING; TEA; 4-AP;

D O I：

10.1016/0006-8993(92)91566-W

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The sensitivity of a transient outward rectifier in guinea-pig substantia nigra pars compacta (SNC) neurones in vitro was tested to a variety of ion channel blocking agents. This rectification was not blocked by TEA (10 mM), 4-aminopyridine (4-AP) (5 mM), apamin (0.2-1 muM) or Cd2+ ions (200 muM). Cs+ ions (5 mM) blocked the inward 'anomalous' rectifier but had no effect on the transient outward rectification. However, replacing Ca2+ ions in the bath perfusate by Ba2+ blocked the transient outward but not the inward rectifier. It is suggested that an atypical barium-sensitive conductance is responsible for the transient outward rectification of these neurones.

引用

页码：325 / 329

页数：5

共 29 条

[1] SINGLE APAMIN-BLOCKED CA-ACTIVATED K+ CHANNELS OF SMALL CONDUCTANCE IN CULTURED RAT SKELETAL-MUSCLE
BLATZ, AL
MAGLEBY, KL
[J]. NATURE, 1986, 323 (6090) : 718 - 720
[2] APAMIN AND D-TUBOCURARINE BLOCK THE AFTER-HYPERPOLARIZATION OF RAT SUPRAOPTIC NEUROSECRETORY NEURONS
BOURQUE, CW
BROWN, DA
[J]. NEUROSCIENCE LETTERS, 1987, 82 (02) : 185 - 190
[3] TOXINS IN THE CHARACTERIZATION OF POTASSIUM CHANNELS
CASTLE, NA
HAYLETT, DG
JENKINSON, DH
[J]. TRENDS IN NEUROSCIENCES, 1989, 12 (02) : 59 - 65
[4] CHIODO LA, 1987, NEUROPHYSIOLOGY DOPA, P67
[5] AUTOGENOUS OSCILLATORY POTENTIALS IN NEURONS OF THE GUINEA-PIG SUBSTANTIA NIGRA PARS COMPACTA INVITRO
FUJIMURA, K
MATSUDA, Y
[J]. NEUROSCIENCE LETTERS, 1989, 104 (1-2) : 53 - 57
[6] GRACE AA, 1984, J NEUROSCI, V4, P2877
[7] NIGRAL DOPAMINE NEURONS - INTRACELLULAR-RECORDING AND IDENTIFICATION WITH L-DOPA INJECTION AND HISTOFLUORESCENCE
GRACE, AA
BUNNEY, BS
[J]. SCIENCE, 1980, 210 (4470) : 654 - 656
[8] GRACE AA, 1989, J NEUROSCI, V9, P3463
[9] Grace AA., 1987, NEUROPHYSIOLOGY DOPA, P1
[10] 2 TRANSIENT OUTWARD CURRENTS IN HISTAMINE NEURONS OF THE RAT HYPOTHALAMUS INVITRO
GREENE, RW
HAAS, HL
REINER, PB
[J]. JOURNAL OF PHYSIOLOGY-LONDON, 1990, 420 : 149 - 163

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