SENSITIVITY OF TRANSIENT OUTWARD RECTIFICATION TO ION CHANNEL BLOCKING-AGENTS IN GUINEA-PIG SUBSTANTIA-NIGRA PARS COMPACTA NEURONS INVITRO

被引：10

作者：

HARRIS, NC

机构：

[1] University Department of Pharmacology, Oxford

来源：

BRAIN RESEARCH | 1992年 / 596卷 / 1-2期

关键词：

APAMIN; BARIUM; CESIUM; CADMIUM; ION CHANNEL BLOCKER; INTRACELLULAR RECORDING; TEA; 4-AP;

D O I：

10.1016/0006-8993(92)91566-W

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The sensitivity of a transient outward rectifier in guinea-pig substantia nigra pars compacta (SNC) neurones in vitro was tested to a variety of ion channel blocking agents. This rectification was not blocked by TEA (10 mM), 4-aminopyridine (4-AP) (5 mM), apamin (0.2-1 muM) or Cd2+ ions (200 muM). Cs+ ions (5 mM) blocked the inward 'anomalous' rectifier but had no effect on the transient outward rectification. However, replacing Ca2+ ions in the bath perfusate by Ba2+ blocked the transient outward but not the inward rectifier. It is suggested that an atypical barium-sensitive conductance is responsible for the transient outward rectification of these neurones.

引用

页码：325 / 329

页数：5

共 29 条

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