HAILEY-HAILEY DISEASE - A WIDESPREAD ABNORMALITY OF CELL-ADHESION

被引：35

作者：

BURGE, SM ^{[1
]}

MILLARD, PR ^{[1
]}

WOJNAROWSKA, F ^{[1
]}

机构：

[1] JOHN RADCLIFFE HOSP,DEPT HISTOPATHOL,OXFORD OX3 9DU,ENGLAND

来源：

BRITISH JOURNAL OF DERMATOLOGY | 1991年 / 124卷 / 04期

关键词：

D O I：

10.1111/j.1365-2133.1991.tb00592.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Suction has been used to investigate cell adhesion in clinically normal skin in Hailey-Hailey disease. We have demonstrated that there is a widespread subclinical abnormality in keratinocyte adhesion in this disease. There may be a synthesis of functionally deficient adhesion junctions, increased breakdown of adhesion junctions or abnormalities in other adhesion proteins in the epidermis in Hailey-Hailey disease. The findings contrast with those in Darier's disease in which abnormal cell adhesion was only demonstrable in clinically involved skin.

引用

页码：329 / 332

页数：4