NEUROFIBRILLARY TANGLES IN THE CEREBRAL-CORTEX OF SHEEP

被引：72

作者：

NELSON, PT

GREENBERG, SG

SAPER, CB

机构：

[1] BETH ISRAEL HOSP, DEPT NEUROL, BOSTON, MA 02215 USA

[2] BETH ISRAEL HOSP, PROGRAM NEUROSCI, BOSTON, MA 02215 USA

[3] HARVARD UNIV, SCH MED, BOSTON, MA 02115 USA

[4] BURKE MED RES INST, WHITE PLAINS, NY 10605 USA

[5] UNIV CHICAGO, BRAIN RES INST, CHICAGO, IL 60637 USA

[6] UNIV CHICAGO, COMM NEUROBIOL, CHICAGO, IL 60637 USA

来源：

NEUROSCIENCE LETTERS | 1994年 / 170卷 / 01期

关键词：

ALZHEIMERS DISEASE; NEUROFIBRILLARY TANGLE; PAIRED HELICAL FILAMENT; TAU; PLAQUE; AMYLOID; SHEEP; ANIMAL MODEL;

D O I：

10.1016/0304-3940(94)90270-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Neurofibrillary degeneration, including neurofibrillary tangles (NFTs) and neuritic plaques, is an important pathological hallmark of Alzheimer's disease (AD). Unfortunately, no practical animal model of neurofibrillary degeneration has been described. We report here the presence of structures in the cerebral cortex of sheep, Ovis aries, that resemble Alzheimer NFTs and neuritic plaques. NFT-like structures and clusters of degenerating neurites are stained by silver impregnation and thioflavin-S, and are immunoreactive with antibodies against tau microtubule-associated proteins. Viewed under the electron microscope, tau-immunoreactive tangles consist of paired helical filaments. Naturally occurring neurofibrillary structures in sheep cortex provide a model for studying the pathobiology of Alzheimer's disease.

引用

页码：187 / 190

页数：4

共 26 条

[21] BETA-AMYLOID PRECURSOR PROTEIN OF ALZHEIMER-DISEASE OCCURS AS 110-KILODALTON TO 135-KILODALTON MEMBRANE-ASSOCIATED PROTEINS IN NEURAL AND NONNEURAL TISSUES [J].