CHANGES IN INTESTINAL FUNCTION OF RATS INITIATED WITH DMH AND FED VARYING LEVELS OF BUTTERFAT, CALCIUM, AND MAGNESIUM

被引：9

作者：

BEHLING, AR

KAUP, SM

GREGER, JL

机构：

[1] Department of Nutritional Sciences, University of Wisconsin, Madison, WI 53706

来源：

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL | 1990年 / 13卷 / 03期

关键词：

D O I：

10.1080/01635589009514059

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The effects of dietary calcium, mcgnesium and butterfat on intestinal function and flora in rats initiated with 1, 2-dimethy{hydrazine (DMH) were studied. Male weanling rats were assigned to six isocaloric diets that vcried in their levels of calcium and magnesium (0.25% Ca with 0.05% Mg, 1.0% Ca with 0.05% Mg, or 0.625% Ca with 0.50% Mg) and butterfat (5% or 20%). One-half of the rats in each treatment were injected subcutaneously with DMH weekly for four weeks. This short-term exposure to DMH increased colonic ornithine decarboxylase (ODC) activity and ti e mass of cecal contents. Ingestion of the high levels of either calcium or magnesium depressed colonic ODC activity and depressed apparent absorption of organic matter, calcium, magnesium, and phosphorus. Ingestion of excess magnesium increased the mass of the cecal contents by twofold, caused hypertrophy of cecal walls, and increased the total amount of protein and total nitroreductase and β-glucuronidase activity in the ceca of rats. Ingestion of supplemental calcium had less dramatic effects and increased the mass of cecal contents by only 28% and decreased the total amount of protein in the ceca. On the basis of their different effects on cecal microflora, magnesium appears to have less potential than does calcium as a protective agent against colon cancer. © 1990, Taylor & Francis Group, LLC. All rights reserved.

引用

页码：189 / 199

页数：11

共 30 条

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