REFERENCE INTERVALS FOR TRACE-ELEMENTS IN BLOOD - SIGNIFICANCE OF RISK-FACTORS

被引：131

作者：

GRANDJEAN, P ^{[1
]}

NIELSEN, GD ^{[1
]}

JORGENSEN, PJ ^{[1
]}

HORDER, M ^{[1
]}

机构：

[1] ODENSE UNIV HOSP,DEPT CLIN CHEM,DK-5000 ODENSE,DENMARK

来源：

SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION | 1992年 / 52卷 / 04期

关键词：

ALUMINUM; CADMIUM; COPPER; FLUORIDE; LEAD; MERCURY; NICKEL; SELENIUM; ZINC;

D O I：

10.3109/00365519209088366

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

A random sample of 100 men and 100 women was examined for whole-blood concentrations of mercury, lead, cadmium and selenium, and the serum concentrations of selenium, nickel, fluoride, aluminium, zinc and copper. Major predictors were sex, hormonal factors (pregnancy, menopause, use of oral contraceptives), age, tobacco smoking and alcohol drinking. Among notable associations, increased blood-mercury was related to the presence of more than four amalgam fillings in the teeth. Blood-mercury correlated with blood-selenium, but a relation to fish intake could only be demonstrated for the former parameter. In women, blood-lead appeared to increase with age, with the highest levels seen after the menopause. Serum-nickel was slightly lower in patients with nickel-related contact eczema. Only the selenium concentrations showed a slight increase in individuals taking mineral supplements. Serum-zinc concentrations decreased considerably during the day. Thus, due to the substantial influence of physiological and environmental factors, individual results must be interpreted in the light of the known predictors for the trace element concentration. However, population-based reference intervals for trace elements in blood are useful to explore geographic and temporal variations.

引用

页码：321 / 337

页数：17

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