CHIRAL, BISFUNCTIONALIZATION OF SUBSTRATES - A POWERFUL STRATEGY FOR THE ASYMMETRIC-SYNTHESIS OF C2 SYMMETRIAL COMPOUNDS AND ITS APPLICATION TO THE SYNTHESIS OF ENANTIOMERICALLY PURE TRANS-1,3-DITHIANE 1,3-DIOXIDE

We have found that the chiral, bisfunctionalization of substrates is a powerful strategy for the preparation Of C2 symmetric compounds with very high enantiomeric excess, and by applying this strategy with the Modena method for the asymmetric oxidation of sulfides we have prepared (1R,3R)-1,3-dithiane 1,3-dioxide (1) in enantiomerically pure form.