BIOLOGICAL RESPONSE MODIFIERS RENDER TUMOR-CELLS SUSCEPTIBLE TO AUTOLOGOUS EFFECTOR MECHANISMS BY INFLUENCING ADHESION RECEPTORS

被引：12

作者：

SCHIRREN, CA ^{[1
]}

VOLPEL, H ^{[1
]}

HOFFMANN, JC ^{[1
]}

HENNING, SW ^{[1
]}

QIAO, L ^{[1
]}

AUTSCHBACH, F ^{[1
]}

DENGLER, TJ ^{[1
]}

DOHNER, H ^{[1
]}

MEUER, SC ^{[1
]}

机构：

[1] DEUTSCH KREBSFORSCHUNGSZENTRUM,ANGEW IMMUNOL,NEUENHEIMER FELD 280,W-6900 HEIDELBERG,GERMANY

来源：

LEUKEMIA & LYMPHOMA | 1993年 / 10卷 / 1-2期

关键词：

ADHESION MOLECULES; T-CELL LEUKEMIA; CYTOKINES; EFFECTOR MECHANISMS;

D O I：

10.3109/10428199309147353

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Adhesion molecules such as CD2 and its ligand CD58 (LFA-3), as well as CD11a/18 (LFA-1) and CD54 (ICAM-1) regulate not only cell to cell attachment but also participate in lymphocyte activation, recirculation, and effector function including cytolytic activity towards tumor cells. We have investigated the role of CD2/CD58 and CD11a/18/CD54 interactions in cellular immune responses directed towards freshly recovered human T cell leukemias. Downregulation of CD54 and CD58 were observed to correlate with enhanced numbers of blasts in circulation and lack of susceptibility to killing by autologous cytotoxic lymphocytes. Furthermore, culturing tumor cells with recombinant TNF-alpha conditioned medium resulted in reinduction of CD54 and CD58 expression and susceptibility to lymphocyte mediated lysis in vitro. Our findings support the view that adhesion molecules play a pivotal role for tumor cell biology in vivo and stress the point that successful immunotherapy of malignant disease may be facilitated by influencing not only the immune response itself but also adhesion molecules on the malignant tumor targets.

引用

页码：25 / 33

页数：9

共 31 条

[21]

Dustin M.L., Singer K.H., Tuck D.T., Springer T.A., Adhesion of lymphoblasts to epidermal keratinocytes is regulated by Interferon-gamma and is mediated by intercellular adhesion molecule 1 (ICAM-1), J. Exp. Med, 167, pp. 1323-1340, (1988)

[22]

Cosimi A.B., Conti D., Delmonico F.L., Et al., In vivo effects of monoclonal antibody to ICAM-1 (CD54) in non-human primates with renal allografts, J. Immunol., 144, pp. 4604-4612, (1990)

[23]

Schirren C.A., Volpel H., Meuer S.C., Adhesion molecules on freshly recovered T leukemias promote tumor-directed lympholysis, Blood, 79, pp. 138-143, (1992)

[24]

Billaud M., Calender A., Seigneurin J.M., Lenoir G.M., LFA-1, LFA-3, and ICAM-1 expression in Burkitts lymphoma, Lancet, II, pp. 1327-1331, (1992)

[25]

Gregory C.D., Murray R.J., Edwards C.F., Rickinson A.B., Downregulation of cell adhesion molecules LFA-3 and ICAM-1 in Epstein-Barr virus-positive Burkitts lymphoma underlies tumor cell escape from virus-specific T cell surveillance, J. Exp. Med, 167, pp. 1811-1824, (1988)

[26]

Bennett J.M., Catovsky D., Daniel M.T., Et al., Proposals for classification of chronic (mature) B and T lymphoid leukaemias, J. Clin. Pathol, 42, pp. 567-584, (1989)

[27]

Rabinowitz R., Polliack A., Leizerowitz R., Keren-Zur Y., Schlesinger M., Expression of CD11a (LFA-1) on B-chronic lymphocytic leukemia and lymphoma cells: correlation with cell surface immunoglobulin intensity and CD58 (LFA-3) expression, Leukemia and Lymphoma, pp. 59-64, (1991)

[28]

Horst E., Radaszkiewicz T., Hooftman-den Otter A., Pieters R., van Dongen J.J.M., Meijer C.J.L.M., Pals S.T., Expression of leukocyte integrin LFA-1 (CD 11 a/CD 18) and its ligand ICAM-1 (CD54) in lymphoid malignancies is related to lineage derivation and stage of differentiation but not to tumor grade, Leukemia, 5, pp. 848-853, (1991)

[29]

Upadhyaya G., Guba S.C., Sih S.A., Et al., Interferon-alpha restores the deficient expression of cytoadhesion molecule lymphocyte function antigen-3 by chronic myelogenous leukemia progenitor cells, J. Clin. Invest., 88, pp. 2131-2136, (1991)

[30]

Fisch P., Weil-Hillmann G., Uppenkamp M., Chen B.P., Sosman J.A., Bridges A., Colamonici O.R., Sondel P.M., Antigen-specific recognition of autologous leukemia cells and allogeneic class-I MHC antigens by IL-2 activated cytotoxic T cells from a patient with acute T-cell leukemia, Blood, 74, pp. 343-353, (1989)

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