THE EFFECT OF NITRIC-OXIDE GENERATORS ON ISCHEMIA REPERFUSION INJURY AND HISTAMINE-RELEASE IN ISOLATED PERFUSED GUINEA-PIG HEART

被引：38

作者：

MASINI, E ^{[1
]}

BIANCHI, S ^{[1
]}

MUGNAI, L ^{[1
]}

GAMBASSI, F ^{[1
]}

LUPINI, M ^{[1
]}

PISTELLI, A ^{[1
]}

MANNAIONI, PF ^{[1
]}

机构：

[1] UNIV FLORENCE,DEPT ANIM BIOL,I-50134 FLORENCE,ITALY

来源：

AGENTS AND ACTIONS | 1991年 / 33卷 / 1-2期

关键词：

D O I：

10.1007/BF01993125

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Experiments were carried out to provide evidence of the effect of L-arginine (L-Arg), its analogue N(G)-monomethyl-L-arginine (MeArg) and of some nitrovasodilators (sodium nitroprusside, NaNP; 3-morpholino-sydnonimine, SIN-1) which spontaneously release nitric oxide (NO) on ischemia-reperfusion injury, histamine release and mast cell degradulation, occurring after multiple igature and release of the left anterior descending (LAD) coronary artery in isolated perfused guinea-pig hearts. The reopening of the LAD coronary artery leads to a release of histamine related to a decrease in microdensitometry of cardiac mast cells and to calcium overload. The perfusion of the heart with NO-donors significantly reduces either the release of histamine, the loss of mast cell metachromasia and the overload of calcium. These effects were potentiated by SOD. The results suggest that the endogenous formation of NO and molecules able to generate NO have a role in the prevention of post-ischemic tissue injury.

引用

页码：53 / 56

页数：4

共 10 条

[1]

Brunton T. L., 1867, LANCET, V2, P97, DOI DOI 10.1016/S0140-6736(02)51392-1

[2] CORRELATION BETWEEN NITRIC-OXIDE FORMATION DURING DEGRADATION OF ORGANIC NITRATES AND ACTIVATION OF GUANYLATE-CYCLASE [J].