TUMOR SUPPRESSOR GENES

被引：1494

作者：

WEINBERG, RA ^{[1
]}

机构：

[1] MIT, CAMBRIDGE, MA 02139 USA

来源：

SCIENCE | 1991年 / 254卷 / 5035期

关键词：

D O I：

10.1126/science.1659741

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

For the past decade, cellular oncogenes have attracted the attention of biologists intent on understanding the molecular origins of cancer. As the present decade unfolds, oncogenes are yielding their place at center stage to a second group of actors, the tumor suppressor genes, which promise to teach us equally important lessons about the molecular mechanisms of cancer pathogenesis.

引用

页码：1138 / 1146

页数：9

共 237 条

[1] ALTERATIONS IN THE P53 GENE AND THE CLONAL EVOLUTION OF THE BLAST CRISIS OF CHRONIC MYELOCYTIC-LEUKEMIA
AHUJA, H
BARELI, M
ADVANI, SH
BENCHIMOL, S
CLINE, MJ
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (17) : 6783 - 6787
[2] BADER SA, 1991, CELL GROWTH DIFFER, V2, P245
[3] ADENOVIRUS E1A PROTEINS CAN DISSOCIATE HETEROMERIC COMPLEXES INVOLVING THE E2F TRANSCRIPTION FACTOR - A NOVEL MECHANISM FOR E1A TRANSACTIVATION
BAGCHI, S
RAYCHAUDHURI, P
NEVINS, JR
[J]. CELL, 1990, 62 (04) : 659 - 669
[4] THE RETINOBLASTOMA PROTEIN COPURIFIES WITH E2F-I, AN E1A-REGULATED INHIBITOR OF THE TRANSCRIPTION FACTOR E2F
BAGCHI, S
WEINMANN, R
RAYCHAUDHURI, P
[J]. CELL, 1991, 65 (06) : 1063 - 1072
[5] SUPPRESSION OF HUMAN COLORECTAL-CARCINOMA CELL-GROWTH BY WILD-TYPE-P53
BAKER, SJ
MARKOWITZ, S
FEARON, ER
WILLSON, JKV
VOGELSTEIN, B
[J]. SCIENCE, 1990, 249 (4971) : 912 - 915
[6] BAKER SJ, 1990, CANCER RES, V50, P7717
[7] CHROMOSOME-17 DELETIONS AND P53 GENE-MUTATIONS IN COLORECTAL CARCINOMAS
BAKER, SJ
FEARON, ER
NIGRO, JM
HAMILTON, SR
PREISINGER, AC
JESSUP, JM
VANTUINEN, P
LEDBETTER, DH
BARKER, DF
NAKAMURA, Y
WHITE, R
VOGELSTEIN, B
[J]. SCIENCE, 1989, 244 (4901) : 217 - 221
[8] THE NF1 LOCUS ENCODES A PROTEIN FUNCTIONALLY RELATED TO MAMMALIAN GAP AND YEAST IRA PROTEINS
BALLESTER, R
MARCHUK, D
BOGUSKI, M
SAULINO, A
LETCHER, R
WIGLER, M
COLLINS, F
[J]. CELL, 1990, 63 (04) : 851 - 859
[9] CYCLIN-A AND THE RETINOBLASTOMA GENE-PRODUCT COMPLEX WITH A COMMON TRANSCRIPTION FACTOR
BANDARA, LR
ADAMCZEWSKI, JP
HUNT, T
LATHANGUE, NB
[J]. NATURE, 1991, 352 (6332) : 249 - 251
[10] ADENOVIRUS-E1A PREVENTS THE RETINOBLASTOMA GENE-PRODUCT FROM COMPLEXING WITH A CELLULAR TRANSCRIPTION FACTOR
BANDARA, LR
LATHANGUE, NB
[J]. NATURE, 1991, 351 (6326) : 494 - 497

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