TUMOR SUPPRESSOR GENES

被引:1494
作者
WEINBERG, RA [1 ]
机构
[1] MIT, CAMBRIDGE, MA 02139 USA
关键词
D O I
10.1126/science.1659741
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
For the past decade, cellular oncogenes have attracted the attention of biologists intent on understanding the molecular origins of cancer. As the present decade unfolds, oncogenes are yielding their place at center stage to a second group of actors, the tumor suppressor genes, which promise to teach us equally important lessons about the molecular mechanisms of cancer pathogenesis.
引用
收藏
页码:1138 / 1146
页数:9
相关论文
共 237 条
  • [71] FAMILIAL PREDISPOSITION TO WILMS TUMOR DOES NOT MAP TO THE SHORT ARM OF CHROMOSOME-11
    GRUNDY, P
    KOUFOS, A
    MORGAN, K
    LI, FP
    MEADOWS, AT
    CAVENEE, WK
    [J]. NATURE, 1988, 336 (6197) : 374 - 376
  • [72] INHIBITION OF GROWTH FACTOR-INDUCED DIFFERENTIATION OF PC12 CELLS BY MICROINJECTION OF ANTIBODY TO RAS P21
    HAGAG, N
    HALEGOUA, S
    VIOLA, M
    [J]. NATURE, 1986, 319 (6055) : 680 - 682
  • [73] OSTEO-SARCOMA AND RETINOBLASTOMA - A SHARED CHROMOSOMAL MECHANISM REVEALING RECESSIVE PREDISPOSITION
    HANSEN, MF
    KOUFOS, A
    GALLIE, BL
    PHILLIPS, RA
    FODSTAD, O
    BROGGER, A
    GEDDEDAHL, T
    CAVENEE, WK
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (18) : 6216 - 6220
  • [74] HANSEN MF, 1987, CANCER RES, V47, P5518
  • [75] ABNORMALITIES IN STRUCTURE AND EXPRESSION OF THE HUMAN RETINOBLASTOMA GENE IN SCLC
    HARBOUR, JW
    LAI, SL
    WHANGPENG, J
    GAZDAR, AF
    MINNA, JD
    KAYE, FJ
    [J]. SCIENCE, 1988, 241 (4863) : 353 - 357
  • [76] COMPLEX OF SIMIAN VIRUS-40 LARGE-T ANTIGEN AND HOST 53,000-MOLECULAR-WEIGHT PROTEIN IN MONKEY CELLS
    HARLOW, E
    PIM, DC
    CRAWFORD, LV
    [J]. JOURNAL OF VIROLOGY, 1981, 37 (02) : 564 - 573
  • [77] CANCER GENES - TELLING CHANGES OF BASE
    HARRIS, AL
    [J]. NATURE, 1991, 350 (6317) : 377 - 378
  • [78] HARRIS H, 1988, CANCER RES, V48, P3302
  • [79] SUPPRESSION OF MALIGNANCY BY CELL FUSION
    HARRIS, H
    MILLER, OJ
    KLEIN, G
    WORST, P
    TACHIBANA, T
    [J]. NATURE, 1969, 223 (5204) : 363 - +
  • [80] HELDIN CH, 1984, CELL, V37, P9, DOI 10.1016/0092-8674(84)90296-4