VITAMIN-C AND VITAMIN-E DONATE SINGLE HYDROGEN-ATOMS INVIVO

被引：103

作者：

NJUS, D

KELLEY, PM

机构：

[1] Department of Biological Sciences, Wayne State University, Detroit

来源：

FEBS LETTERS | 1991年 / 284卷 / 02期

关键词：

ASCORBIC ACID; TOCOPHEROL; SUPEROXIDE ANION; FREE RADICAL SCAVENGING; REDOX; REACTION RATE;

D O I：

10.1016/0014-5793(91)80672-P

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The antioxidant vitamins, C and E, eliminate cytotoxic free radicals by redox cycling. Energetic and kinetic considerations suggest that cycling of vitamin C and vitamin E between their reduced and free radical forms occurs via the transfer of single hydrogen atoms rather than via separate electron transfer and protonation reactions. This may enable these vitamins to reduce many of the damaging free radicals commonly encountered by biological systems while minimizing the reduction of molecular oxygen to superoxide.

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页码：147 / 151

页数：5

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